部分发表论文列表 « †joint first author, *corresponding author » ● Han X†*, Gharahkhani P†, Hamel AR, Ong JS, …,
Hewitt AW, Craig JE, Pasquale LR, Mackey DA, Wiggs JL, Khawaja AP, Segrè
AV, MacGregor S. Large scale multi-trait genome-wide association
analysis identifies hundreds of glaucoma risk loci. Nature Genetics. 2023; 55(7):1116-1125 ● Craig JE†, Han X†*, Qassim A†, Hassall M, …, Wiggs JL, Hewitt
AW, MacGregor S. Multitrait analysis of glaucoma identifies new loci and
enables effective polygenic risk score prediction of disease
susceptibility, progression. Nature Genetics. 2020; 52(2):160-166. ● Han X*, Steven K, Qassim A, Marshall HN, Bean C,
Tremeer M, An J, Siggs OM, Gharahkhani P, Craig JE, Hewitt AW,
Trzaskowski M, MacGregor S. Automated AI labelling of optic nerve head
enables new insights into cross-ancestry glaucoma risk and genetic
discovery in >280,000 images from UKB and CLSA. American Journal of Human Genetics. 2021; 108(7):1204-1216. ● Han X*, Lains I, Li J, Li J, Chen Y, Yu B, Qi Q,
Boerwinkle E, Kaplan R, Thyagarajan B, Daviglus M, Joslin CE, …, Miller
J, Hu F, Willett W, Lasky-Su J, Kraft P, Richards JB, MacGregor S,
Husain D, Liang L. Integrating genetics and metabolomics from
multi-ethnic and multi-fluid data reveals putative mechanisms for
age-related macular degeneration. Cell Reports Medicine. 2023;4(7):101085. ● Han X*, Hewitt AW, MacGregor S. Predicting the future of genetic risk profiling of glaucoma: a narrative review. JAMA ophthalmology. 2021;139(2):224-231. ● Han X†, Souzeau E†, Ong JS, An J, Siggs OM, Burdon
KP, …, Hewitt AW, Gharahkhani P, Craig JE, MacGregor S. Myocilin Gene
Gln368Ter Variant Penetrance and Association With Glaucoma in
Population-Based and Registry-Based Studies. JAMA Ophthalmology. 2019; 137(1):28-35. ● Han X*, Gharahkhani P, Mitchell P, Liew G, Hewitt
AW, MacGregor S. Meta-analysis of genome-wide association studies
identify novel genes for age-related macular degeneration. Journal of Human Genetics. 2020; 65(8):657-665. ● Han X*, Ong JS, Hewitt AW, Gharahkhani P,
MacGregor S. The effects of eight serum lipid biomarkers on age-related
macular degeneration risk: a Mendelian randomization study. International journal of epidemiology. 2021; 50(1):325-336. ● Han X*, Liang L*. metabolomicsR: a streamlined workflow to analyze metabolomic data in R. Bioinformatics Advances. 2022; 2(1):vbac067. « co-author » ● Daniszewski M, Senabouth A, Liang LH, Han X, Lidgerwood GE, Hernández D, …, Mackey DA,
Craig JE, MacGregor S, Powell JE, Pébay A, Hewitt AW. Retinal ganglion
cell-specific genetic regulation in primary open angle glaucoma. Cell Genomics 2022, 2, 100142. ● Senabouth A, Daniszewski M, Lidgerwood GE, Liang HH, Hernández D, Mirzaei M, Keenan SN, Zhang R, Han X, Neavin D, Rooney L,… , Mackey DA, Bylsma
G, Verma N, MacGregor S, Watt MJ, Guymer RH, Powell JE, Hewitt AW, Pébay
A. Transcriptomic and proteomic retinal pigment epithelium signatures
of age-related macular degeneration. Nature Communications. 2022 26;13(1):4233. ● Gharahkhani P., Jorgenson E., Hysi P., Khawaja A.P., Pendergrass S., Han X, Ong J.S., Hewitt A. W., …, Mackey D.A.,
Kubo M., Aung T., Craig J. E., MacGregor S., Wiggs J. L.. Genome-wide
meta-analysis identifies 127 open-angle glaucoma loci with consistent
effect across ancestries. Nature Communications. 2021;12(1):1258. ● Ong JS, An J, Han X, Law MH, Nandakumar P, …, Gharahkhani P,
Kendall BJ, MacGregor S. Multitrait genetic association analysis
identifies 50 new risk loci for gastro-oesophageal reflux, seven new
loci for Barrett’s oesophagus and provides insights into clinical
heterogeneity in reflux diagnosis. Gut. 2021; gutjnl-2020-323906. ● MacGregor S, Ong JS, An J, Han X, Zhou T, Siggs OM, …, Mackey DA,
Gharahkhani P, Craig JE, Hewitt AW. Genome-wide association study of
intraocular pressure uncovers new pathways to glaucoma. Nature Genetics. 2018; 50(8):1067-1071. |